Isatis.py is a Python geostatistical library that provides a wide range of tools and geostatistical techniques for geostatisticians, consultant geologists, mining engineers, and resource teams to deliver robust and accurate resource models and make effective decisions. Isatis.py offers the robust and technologically advanced geostatistical algorithms found in Isatis.neo. Isatis.py benefits from the Python ecosystem and gives direct access to a vast range of Python libraries. Hence, users can combine geostatistics with machine learning techniques to solve real and complex geostatistical problems.